At first, Haddish appeared in television series in episodic roles, but then she grabbed the role of Nekeysha Williams in the NBC sitcom The Carmichael Show, after which she received her first fame. In 2016, the actress could be seen in the comedy film Keanu with Jordan Peele in the title role, and in 2017 in the comedy Crazy Families with Charlie Sheen. Haddish's breakthrough was the film "Girls Awesome", which was released in July 2017. The actress's colleagues on the set were the well-known Queen Latifah, Regina Hall and Jada Pinkett Smith. Haddish received critical acclaim for her work in the film. That same year, she published her memoirs, giving them the title The Last Black Unicorn.
In 2018, the actress starred in the melodrama “Night School” together with Kevin Hart, and in 2019 one could hear the voice of Tiffany Haddish in the original dubbing of the cartoons “The Secret Life of Pets 2”, “Lego. Movie 2" and "Angry Birds at the Movie 2". In the first, she voiced the Shih Tzu dog Daisy, in the second, Queen Many-Faced Beautiful, and in the third, Debbie the bird. In 2019, the actress starred in the crime action film Hell's Kitchen in the company of such actors as Melissa McCarthy, Elisabeth Moss and Domhnall Gleeson.
In 2020, Tiffany Haddish played the lead role in the comedy film Glam Bosses. In 2021, she also appeared in the movie Funny People on the Road.