Genesis Rodriguez was born on July 29, 1987 in Miami, Florida. Her mother, Carolina Pérez, is a Cuban model. Her father, José Luis Rodríguez, is a Venezuelan actor and singer who is also known by the nickname "El Puma". She began her career playing leading roles in the Telemundo telenovelas Prisionera (2004), Dame Chocolate (2007) and Doña Bárbara (2008–2009). She played Sarah on Entourage (2010–2011) and assistant museum curator/adventurer Jane Walker on Time After Time (2017), and has starred in the films Man on a Ledge (2012), Casa de Mi Padre (2012), What to Expect When You're Expecting (2012), The Last Stand (2013), Tusk (2014) and Run All Night (2015). She provided the voice for Honey Lemon in Big Hero 6 (2014), a role she will reprise in the upcoming TV series (2017).

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