George Clooney was born on May 6, 1961 in Lexington, Kentucky. His mother, Nina Bruce (née Warren; born 1939), was a beauty queen and city councilwoman. His father, Nick Clooney (born 1934), is a former anchorman and television host, including five years on the AMC network. Clooney has Irish, German, and English ancestry.
He began his education at the Blessed Sacrament School in Fort Mitchell, Kentucky. He attended St. Michael's School in Columbus, Ohio; then Western Row Elementary School (a public school) in Mason, Ohio, from 1968 to 1974; and St. Susanna School in Mason, where he served as an altar boy. After his parents moved to Augusta, Kentucky, Clooney attended Augusta High School. He has stated that he earned all As and a B in school, and was an enthusiastic baseball and basketball player. He tried out to play professional baseball with the Cincinnati Reds in 1977, but he did not pass the first round of player cuts and was not offered a contract. He attended Northern Kentucky University from 1979 to 1981, majoring in broadcast journalism, and very briefly attended the University of Cincinnati, but did not graduate from either. He made money selling women's shoes, insurance door-to-door, stocking shelves, working construction, and cutting tobacco. Clooney's first role was as an extra in the television mini-series Centennial in 1978, which was based on the novel of the same name by James A. Michener and was partly filmed in Clooney's hometown of Augusta, Kentucky. Clooney's first major role came in 1984 in the short-lived sitcom E/R (not to be confused with ER, the better-known hospital drama, on which Clooney also co-starred a decade later). He played a handyman on the series The Facts of Life and appeared as Bobby Hopkins, a detective, on an episode of The Golden Girls. His first prominent role was a semi-regular supporting role in the sitcom Roseanne, playing Roseanne Barr's supervisor Booker Brooks, followed by the role of a construction worker on Baby Talk, a co-starring role on the CBS drama Bodies of Evidence as Detective Ryan Walker, and then a year-long turn as Det. James Falconer on Sisters. In 1988, Clooney played a role in the comedy-horror film Return of the Killer Tomatoes. In 1990, he starred in the short-lived ABC police drama Sunset Beat. During this period, Clooney was a student at the Beverly Hills Playhouse acting school for five years. Clooney rose to fame when he played Dr. Doug Ross, alongside Anthony Edwards, Julianna Margulies, and Noah Wyle, on the hit NBC medical drama ER from 1994 to 1999. After leaving ER, Clooney starred in the commercially successful films The Perfect Storm (2000), a disaster drama, and O Brother, Where Art Thou? (2000), a Coen brothers adventure comedy. In 2001, he teamed up with Soderbergh again for the heist comedy Ocean's Eleven, a remake of the 1960s Rat Pack film of the same name, with Clooney playing Danny Ocean, originally portrayed by Frank Sinatra. It is Clooney's most successful film with him in the lead role, earning $451 million worldwide (Gravity $723 million overall). The film inspired two sequels starring Clooney, Ocean's Twelve in 2004 and Ocean's Thirteen in 2007. Clooney won an Academy Award for Best Supporting Actor for the Middle East thriller Syriana (2005), and subsequently earned Best Actor nominations for the legal thriller Michael Clayton (2007) and the comedy-dramas Up in the Air (2009) and The Descendants (2011). In 2013, he received the Academy Award for Best Picture for producing the political thriller Argo. He is the only person who has been nominated for Academy Awards in six different categories.

For more information press link below:
https://en.wikipedia.org/wiki/George_Clooney