Rex, Hollywood's top-grossing canine, is known for his extreme athletic abilities and diva-like demeanor. His perks package, rivaling that of any A-list celebrity, includes Kobe beef, a poodle harem, and a diamond collar. Rex's luck--and Hollywood high life--runs out while shooting a commercial. An aerial stunt goes awry, leading Rex's handlers to presume he's dead. But Rex is merely lost--alone, filthy and unrecognizable in an unfamiliar city. Chased by animal control, he takes refuge in grubby abandoned lofts, a far cry from his former luxurious lifestyle. Shane Fahey, a bright but rebellious 12-year-old, has exasperated his father Connor for the umpteenth time. A single parent and captain of the rundown inner city fire station known as Dogpatch, Connor is charged with inspiring the sad-sack company: veteran and firehouse cook Joe Musto, the super-fit and strong-willed mother hen Pepita "Pep" Clemente (Mayte Garcia), the exhausted family-man Lionel Bradford, and the calendar-worthy rookie Terence Kahn. The team is still coping with the recent loss of their former captain, Connor's brother. Shane is also troubled by his uncle's death, and he's been acting out by ditching school.