Miguel Ferrer was born 7 february 1955 in Santa Monica, California, the oldest of five children of Academy Award-winning actor José Ferrer and singer Rosemary Clooney. Ferrer's siblings were sisters, Maria and Monsita, and brothers, Gabriel (later the husband of singer Debby Boone) and actor Rafael. He also had an older sister, Letty (Leticia) Ferrer, from his father José's prior marriage, to Uta Hagen. He was the cousin of actor George Clooney and the nephew of journalist Nick Clooney. Ferrer was raised in Hollywood, California; as a teenager, his interests tended toward music. He played the drums on Keith Moon's Two Sides of the Moon. On January 19, 2017, Ferrer died at his Los Angeles home of throat cancer at the age of 61, brought on by a long chain-smoking habit. He was survived by his wife Lori Weintraub, whom he married in 2005, and his three sons, Lukas (born 1993) and Rafael (born 1996), from his first marriage to Leilani Sarelle (1991–2003), and José Robert Ferrer (born 2004) from his relationship with Kate Dornan. Miguel O'Hara, the alter ego of the Marvel Comics superhero Spider-Man 2099, was named for Ferrer by his friend, writer Peter David, who co-created the character.

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