Bae Doona was born on October 11, 1979 in Seoul, South Korea. Growing up, Bae would follow her mother, Kim Hwa-young, a stage actress in Korea, around the theater and rehearsal halls, learning lines of dialogue as she went along. This did not initially lead Bae towards acting, saying: "People might say that since my mother is a theater actor, I became an actress. But to me, those experiences probably had the opposite effect. On the contrary, because I saw many great actors working with my mother, I thought this was a job only people with extraordinary talent could do."
She became known outside Korea for her roles as a political activist in Park Chan-wook's Sympathy for Mr. Vengeance (2002), archer Park Nam-joo in Bong Joon-ho's The Host (2006), and as an inflatable sex doll-come-to-life in Hirokazu Koreeda's Air Doll (2009). She has had English-speaking roles in the Wachowski films Cloud Atlas (2012) and Jupiter Ascending (2015), and the TV series Sense8 (2015–present).

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