Laura Ziskin was born and raised in a Jewish family in the San Fernando Valley, California, the daughter of Jay Ziskin and Elaine Edelman. Her father was a psychologist and lawyer who died of prostate cancer, aged 77, on June 14, 1997. After graduating from the USC School of Cinematic Arts in 1973, Ziskin began by writing material for game shows, then became the personal assistant of Jon Peters. Ziskin quickly became a development executive, moving into feature films with Jon Peters' production company where she worked on the remake of A Star Is Born (1976), starring Barbra Streisand. She was the associate producer of The Eyes of Laura Mars (1978).

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