When brothers and fellow FBI agents Marcus (Marlon Wayans) and Kevin Copeland (Shawn Wayans) accidentally ruin an otherwise painstakingly executed drug bust, getting back into the good graces of their boss becomes a high-priority assignment in itself. With this in mind, Marcus and Kevin take on a case far beneath their usual standards when they agree to escort socialite sisters Brittany (Maitland Ward) and Tiffany Wilton (Anne Dudek) from a private terminal at JFK Airport to their hotel room in the Hamptons. Once there, two considerably higher-ranking agents will take over the girls' protection. The extra security is no mere perk of wealth, however, as it appears that Brittany and Tiffany have been targeted by a serial kidnapper. The FBI hopes to apprehend the perpetrator by using the girls as bait, unbeknownst to them. The plan may have worked if it weren't for Kevin and Marcus, who manage to let the sisters in on the secret. Understandably, neither of them want any part in the process, so they force the brothers to come up with a radical solution: With the help of an FBI lab scientist, the very much African-American Kevin and Marcus will be transformed into two white women who could pass for Brittany and Tiffany. The agents must keep the charade up long enough to lure the kidnapper, but fooling everyone involved will be the job of their lives.