Dana Scully, a former FBI agent, is now a staff physician at a Catholic hospital; she is treating Christian, a young boy with symptoms similar to Sandhoff disease. FBI agent Mosely Drummy approaches Scully for help in locating her former partner, Fox Mulder, who has been in hiding as a fugitive for several years. Drummy states that the FBI will call off its manhunt for Mulder if he helps investigate the disappearances of several women in West Virginia, the latest of whom is a young FBI agent named Monica Bannan. Scully agrees and convinces a reluctant Mulder to help. The duo are taken to Washington, D.C., where Agent Dakota Whitney requests Mulder's expertise with the paranormal as they have been led to a clue, a severed human arm, by Father Joseph Fitzpatrick Crissman.