Patricia Clarkson was born december 29, 1959 in New Orleans, Louisiana, the daughter of Jackie Clarkson (née Brechtel), a New Orleans politician and councilwoman, and Arthur Clarkson, a school administrator who worked at the Louisiana State University School of Medicine. She is one of five sisters, all of whom attended O. Perry Walker High School. Clarkson studied speech pathology at Louisiana State University, later transferring to Fordham University in New York City, where she graduated summa cum laude with a degree in drama. She then earned her Master of Fine Arts at the Yale School of Drama before making her film debut in The Untouchables in 1987. n response to the Deepwater Horizon oil spill, Clarkson published a post for Natural Resources Defense Council's magazine OnEarth. She also released a public service announcement talking about her experiences growing up in New Orleans. Both pieces were released on July 26, 2010. Clarkson has never married and has no children. Interviewed in 2016, she said, "I've never wanted to marry, I've never wanted children – I was born without that gene."

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