Jessica Rothe was born on May 28, 1978 in Denver, Colorado, the daughter of Susan and Steve Rothenberg. Rothe's father is Jewish her grandmother, Colleen Rothenberg was a theatre actress who belonged to the Congregation Shomrei Torah synagogue in Santa Rosa. She took ballet classes when she was 8. When she was little she attended summer theater camps in Kansas City. Rothe graduated from Boston University in 2009 with a bachelor's degree in Fine Arts, and during that time she learned to play the violin, tap dance and make pottery. She may be best known for her lead role in the 2016 MTV television series Mary + Jane and her starring role in the 2017 horror-comedy film Happy Death Day.

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