Lorenza Izzo was born in Santiago, Chile to Chilean model Rosita Parsons. She has a younger sister, Clara Lyons Parsons, who is a model as well. When she was twelve years old, she moved to Atlanta with her father, then working towards a Ph.D. at Georgia Institute of Technology. She was bullied over her strong Chilean accent as a child, but stated she "got over accent pretty fast" after watching the 2002 sports film Blue Crush several times. Izzo recalls becoming "obsessed with Kate Bosworth" and having "no idea she was Australian — to me she was American and it was all I needed to know". In 2007, Izzo was modeling and studying journalism at the University of Los Andes (Universidad de los Andes) when she moved to New York City to study acting at the Lee Strasberg Theatre and Film Institute. In 2010, she made her debut as an actress in Instrucciones para mi funeral, an independent film made by Sebastián Radic as a graduation project. Her modeling career reached its peak in 2011 when Izzo and her motherwere invited to São Paulo Fashion Week where they met Gisele Bundchen. The meeting resulted in Lorenza becoming the new face of Colcci, a Brazilian fashion company. The same year, Izzo appeared in Que pena tu boda (es) (Sorry About Your Wedding) a comedy by Chilean director Nicolás López. In 2012, with one commercial feature movie to her name and three more then-about to be released Que pena tu familia, Aftershock, and The Green Inferno, Lorenza moved to Los Angeles, when she soon secured small roles in Hemlock Grove and I Am Victor. In 2015, she starred alongside Keanu Reeves and Ana de Armas in Knock Knock, a horror film directed by future husband Eli Roth and filmed in Santiago's Chicureo neighbourhood.

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