Natasa Ninkovic was born on 22 July 1972 in Trebinje (SFR Yugoslavia then, Bosnia and Herzegovina now) to father Branko and mother Milena. She finished her primary and secondary school in Trebinje. In 1994, Ninković graduated at the Faculty of Drama Arts at the University of Belgrade, along with actors Vojin Ćetković, Sergej Trifunović and Nebojša Glogovac. Ninković is married to Nenad Šarenac, with whom she has twins Luka and Matija Šarenac.

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