Dr. Richard Kimble, a prominent Chicago vascular surgeon, arrives home to find his wife Helen fatally wounded by a one-armed man. Kimble struggles with the killer but he escapes. The lack of evidence of a break-in, Helen's lucrative life insurance policy, and a misunderstood 9-1-1 call result in Kimble's wrongful conviction of first-degree murder and a subsequent death sentence. Being transported to death row by bus, his fellow prisoners attempt an escape. The pandemonium sends the bus down a ravine and into the path of an oncoming train. Kimble saves a guard, escapes the collision and flees, while the train derails violently as a result of the collision. Senior Deputy U.S. Marshal Samuel Gerard and his colleagues Renfro, Biggs, Newman and Poole arrive at the crash site and begin the search for Kimble.
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